ea0029p1007 | Male Reproduction | ICEECE2012
Grzesik P.
, Teichmann A.
, Kreuchwig A.
, Furkert J.
, Rutz C.
, Wiesner B.
, Schulein R.
, Gromoll J.
, Krause G.
Activation of the human LH/CG receptor (LH/CGR) by lutropin (LH) and choriogonadotropin (CG) is essential in the human reproduction. Deletion of the Exon10 (LH/CGR-delExon10) resulting in a lack of 27 amino acids within the extracellular hinge-region of LH/CGR causes Leydig cell hypoplasia type II. To clarify why this deletion impairs LH but not CG action, we investigated the molecular determinants of LH/CGR activation elucidating the different behaviour of both hormones.<...